Neurogenesis and Nervous System Development

Front

Neurogenesis & Gliogenesis: Neural plate to neural tube to mature CNS

Back

The process involves the transformation of the neural plate into the neural tube, which eventually matures into the central nervous system (CNS).

Front

Neuroepithelial cells to Neurons and Glia

Back

Neuroepithelial cells differentiate into neurons and glial cells, with neuroepithelial cells being polarized.

Front

Developing Nervous System: Early and Later Stages

Back

During development, layout changes occur, extra layers develop outside the proliferative (ventricular) zone, neurons differentiate in these new layers, and the ventricular zone gradually depletes.

Front

Diagram of early and later stages of nervous system development

Back

The diagram illustrates the changes in the nervous system during early and later stages, highlighting the development of new layers and the depletion of the ventricular zone.

Front

Factors Influencing Neurogenesis: Cell Cycle

Back

The cell cycle plays a crucial role in influencing neurogenesis, affecting how cells proliferate and differentiate.

Front

Cell Polarity

Back

Neural tube from ectoderm forms an epithelium with apical-basal polarity. Epithelia possess apical junctions and are underlain by ECM. During neurulation, orientation moves from dorsal-ventral to medio-lateral.

Front

Epithelial Cell Structure

Back

Illustrates the structure of an epithelial cell with tight and adherens junctions (TJ & AJ) and basal extracellular matrix (ECM).

Front

Zebrafish neural tube with apico-basal polarity

Back

A 36-hour-old zebrafish embryo in transverse section, using immunohistochemistry for apico-basal markers.

Front

Cell cycle + polarity = Interkinetic nuclear migration

Back

Nuclei of neuroepithelial cells traverse the neural tube as they cycle. Nucleus position corresponds with cell cycle stage.

Front

Immunohistochemistry markers

Back

Green = E-cadherin, Yellow = laminin (ECM), Magenta = ZO1 (apical tight junctions), Grey = nuclei.