Proton Pump Inhibitors and Related Conditions

Front

What are proton pump inhibitors (PPIs)?

Back

Efficacious acid inhibitory agents used for the treatment of acid-peptic disorders.

Front

When were proton pump inhibitors introduced?

Back

In the late 1980s.

Front

Name five proton pump inhibitors available for clinical use.

Back

Omeprazole, lansoprazole, rabeprazole, pantoprazole, and esomeprazole.

Front

What is the mechanism of action of proton pump inhibitors?

Back

They block the final common pathway of acid secretion, the proton pump.

Front

How do proton pump inhibitors differ from H2 antagonists?

Back

PPIs inhibit both fasting and meal-stimulated acid secretion, while H2 antagonists do not.

Front

What percentage of 24-hour acid secretion do proton pump inhibitors inhibit?

Back

90–98%.

Front

What is the clinical efficacy of different proton pump inhibitors when administered at equivalent doses?

Back

There is little difference in clinical efficacy.

Front

What is the mean 24-hour intragastric pH range for pantoprazole and esomeprazole at 40 mg?

Back

3.3 (pantoprazole) to 4.0 (esomeprazole).

Front

What is gastroesophageal reflux disease (GERD)?

Back

A condition treated effectively by proton pump inhibitors.

Front

What is the effectiveness of once-daily dosing of PPIs for symptom relief in GERD patients?

Back

85–90% of patients experience effective symptom relief.