PK Module 14: Vancomycin Part 1

Front

Calculate the AUC₂₄ /MIC for a patient receiving a 750 mg vancomycin daily dose with a Cl_vanc = 1.708 L/hr and determine if the dosing is adequate. (MIC to vancomycin = 1 mg/L). AUC_0-24 = Vancomycin Daily Dose/Vancomycin Clearance

Back

Dosing is adequate

Answer explanation

AUC_0-24 = Vancomycin Daily Dose/Vancomycin Clearance = 750 mg / 1.708 L/hr = 439.1 mg*hr/L

This is > 400 mg*hr/L, so therapy is adequate.

Tags

Pharmacokinetics

Front

Calculate the AUC₂₄ /MIC for a patient receiving a 1000 mg vancomycin daily dose with a Cl_vanc = 2.708 L/hr and determine if the dosing is adequate. (MIC to vancomycin = 1 mg/L). AUC_0-24 = Vancomycin Daily Dose/Vancomycin Clearance

Back

Dosing is not adequate. Dose needs to be increased.

Answer explanation

AUC_0-24 = Vancomycin Daily Dose/Vancomycin Clearance = 1000 mg / 2.708 L/hr = 369.3 mg*hr/L

This is < 400 mg*hr/L, so therapy is not adequate.

Tags

Pharmacokinetics

Front

Identify the vancomycin dosing weight to be used in the following scenario: BW, a 42-year-old man, 5' 10'' tall, weighing 80 kg (IBW = 73 kg). Options: Ideal Body Weight, Actual or Total Body Weight, Adjusted Body Weight.

Back

Actual or Total Body Weight

Answer explanation

Use Total Body Weight (TBW)

Tags

Pharmacokinetics

Front

Identify the weight to be used in the CrCl equation for the following scenario: BW, a 42-year-old man, 5' 10'' tall, weighing 80 kg (IBW = 73 kg). Options: Ideal Body Weight, Actual or Total Body Weight, Adjusted Body Weight.

Back

Ideal Body Weight

Answer explanation

Weight = IBW  

UNLESS:

-TBW < IBW - use TBW or if obese use AdjBW

Tags

Pharmacokinetics

Front

Identify the vancomycin dosing weight to be used for LM, a 55-year-old man, 5' 10'' tall, weighing 70 kg (IBW = 73 kg). Options: Ideal Body Weight, Actual or Total Body Weight, Adjusted Body Weight.

Back

Actual or Total Body Weight

Answer explanation

Vancomycin is dosed using TBW

Tags

Pharmacokinetics