Sickle Cell Anemia

Front

What is Sickle Cell Anemia?

Back

A genetic blood disorder characterized by the production of abnormal hemoglobin, leading to distorted (sickle-shaped) red blood cells.

Front

What are the common treatments for Sickle Cell Anemia?

Back

Blood Transfusion, Hydroxyurea, Bone Marrow Transplant.

Front

What is the probability of a child having Sickle Cell Anemia if one parent has normal RBCs and the other has Sickle Cell Disease?

Back

0%.

Front

What amino acid is replaced in Sickle Cell Anemia?

Back

Glutamic Acid is replaced by Valine.

Front

Where are most Sickle Cell Anemia patients located?

Back

Around the Equator.

Front

What process describes the change in amino acids in Sickle Cell RBCs?

Back

Substitution.

Front

What is the role of Hydroxyurea in treating Sickle Cell Anemia?

Back

It helps to increase fetal hemoglobin levels, reducing the frequency of sickle cell crises.

Front

What are the symptoms of Sickle Cell Anemia?

Back

Pain episodes, anemia, swelling in hands and feet, frequent infections.

Front

How does Sickle Cell Anemia affect red blood cells?

Back

It causes them to become rigid and sticky, leading to blockages in blood vessels.

Front

What is the genetic inheritance pattern of Sickle Cell Anemia?

Back

It is inherited in an autosomal recessive pattern.