Hematology Flashcards

Front

What is hematopoiesis?

Back

The process by which blood components are formed from pluripotential stem cells located in the bone marrow, differentiating into RBCs, WBCs, and platelets.

Front

What hormones are involved in hematopoiesis?

Back

Erythropoietin (EPO), Thrombopoietin (TPO), G-CSF, GM-CSF, IL-3, IL-5, IL-6.

Front

What is the primary function of Erythropoietin (EPO)?

Back

To stimulate erythropoiesis and prevent apoptosis of erythroid precursor cells.

Front

What is the lifespan of a red blood cell (RBC)?

Back

120 days.

Front

What is the process of iron metabolism in hemoglobin formation?

Back

Iron (Fe2+) combines with protoporphyrin to form heme, which is part of hemoglobin.

Front

What happens to RBCs during destruction?

Back

RBCs are destroyed through phagocytosis, breaking down hemoglobin into heme and globin.

Front

What is the reference range for WBC count?

Back

4.4-11.3 x 10^3 cells/μL.

Front

What is the reference range for platelet count?

Back

150,000-450,000 cells/μL.

Front

What is the significance of hemoglobin (Hb) levels?

Back

Indicates the capacity of blood to transport oxygen.

Front

What are the reference ranges for hemoglobin in men and women?

Back

Men: 14-17.5 g/dL; Women: 12.3-15.3 g/dL.