SF week 6 flashcard

Front

Gene associated with Fabry disease

Back

GLA

Front

Contraction of the sphincter muscles of the eye results in ___________

Back

Miosis

Front

Vd = ?

Back

Dose/[Dose]plasma

Front

Parasympathetic (muscarinic) agonists result in the ____________ of intraocular pressure

Back

Decrease

Front

Individuals with a __________ isoform result in longer exposure to the active metabolite of tamoxifen, resulting in favorable clinical outcome

Back

CYP2D6 ultra-rapid metabolizer

Front

What is the role of GLA in Fabry disease?

Back

GLA encodes the enzyme alpha-galactosidase A, which is deficient in Fabry disease.

Front

What is miosis?

Back

Miosis is the constriction of the pupil, often in response to light or certain drugs.

Front

Define Vd in pharmacokinetics.

Back

Vd (Volume of Distribution) is a measure of the extent to which a drug is distributed in body tissues.

Front

What effect do muscarinic agonists have on intraocular pressure?

Back

They decrease intraocular pressure.

Front

What is the significance of CYP2D6 in drug metabolism?

Back

CYP2D6 is a key enzyme that metabolizes many drugs, and its activity can vary among individuals.