Complex Traits

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Affected sibling pair study

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A method used in genetics to identify genes associated with a particular trait by studying siblings who both exhibit the trait.

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Coefficient of relatedness

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A measure of how much genetic material is shared between individuals, often used in the context of family genetics.

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Complex trait

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A trait that is influenced by multiple genetic and environmental factors, rather than a single gene.

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Concordance

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The presence of the same trait in both members of a pair of twins or siblings, often used in genetic studies to assess heritability.

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Copy number variant

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A type of genetic variation where the number of copies of a particular gene varies from one individual to the next.

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Empiric risk

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The probability of a trait occurring in a family based on observed data, rather than theoretical calculations.

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Genome wide association study

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A study that involves scanning complete sets of DNA, or genomes, of many people to find genetic variations associated with a particular disease.

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Heritability

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The proportion of observed variation in a particular trait, among individuals in a population, that can be attributed to inherited genetic factors.

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Homozygosity mapping

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A method used to identify disease genes in which researchers look for regions of the genome that are homozygous in affected individuals.

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Incidence

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The rate at which new cases of a disease occur in a population over a specific period.