Myelodysplastic syndromes

Front

Which of the following is the predominant RBC morphology in patients with MDS? Microcytes, Macrocytes, Target cells, Bite cells

Back

Macrocytes

Front

Which diagnosis has the best prognosis? Options: MDS with Excess blasts (RAEB), Refractory anemia with ringed sideroblasts (RARS), Refractory anemia (RA), 5q deletion

Back

Refractory anemia (RA)

Front

What is considered a significant percentage of ringed sideroblasts in the MDS classification?

Back

15%

Front

Which of the following BM blast percentages would be consistent with myelodysplastic syndrome with excess blast 2 (RAEB)? 10%-19%, 20%-30%, >30%, <5%

Back

10%-19%

Front

Which of the following morphological abnormalities are helpful in the diagnosis of MDS? Pseudo-Pelger Huet, Ringed sideroblasts, Pancytopenia, All noted here

Back

All noted here

Front

In female patients with RA and elevated platelet counts, which chromosome abnormality is most often found?

Back

5q-

Front

Which of the following anomalies are important in the pathogenesis of MDS? Chromosomal translocations, Chromosomal deletions, hemolysis, Increased medullary apoptosis

Back

Chromosomal deletions

Front

In addition to the number of blasts, what other criterion is essential for diagnosis of RARS?

Back

At least 15% ringed sideroblasts

Front

The most common cytopenias noted in MDS is

Back

anemia

Front

Progression of MDS to acute leukemia is characterized by: splenomegaly, a decreased M:E, decreased BM cellularity, an increase in blast population

Back

an increase in blast population