Class VII - Linkage + Review

Front

When does recombination occur?

Back

Recombination occurs during Prophase I of meiosis.

Front

What is a dominant negative allele?

Back

A dominant negative allele is a mutant allele that antagonizes the function of the wildtype allele.

Front

What does true breeding mean in genetics?

Back

True breeding refers to a strain of organisms that, when crossed with itself, always produces offspring with the same phenotype.

Front

What is haploinsufficiency?

Back

Haploinsufficiency is a condition where a loss of function allele has a phenotype in heterozygotes, meaning one copy of the gene is not sufficient for normal function.

Front

What are double recombinants in gene mapping?

Back

Double recombinants are the least commonly observed phenotypes in a 3-factor gene mapping cross, resulting from two crossover events.

Front

Define Metaphase I in meiosis.

Back

Metaphase I is the stage in meiosis where homologous chromosomes align at the cell's equatorial plane.

Front

What is the role of Prophase I in meiosis?

Back

Prophase I is crucial for recombination, where homologous chromosomes pair and exchange genetic material.

Front

Explain the concept of gain of function alleles.

Back

Gain of function alleles are mutations that enhance the activity of a gene or result in a new function.

Front

What is a knockout allele?

Back

A knockout allele is a genetically engineered allele that has been inactivated or 'knocked out' to study gene function.

Front

What is incomplete penetrance?

Back

Incomplete penetrance occurs when not all individuals with a particular genotype express the expected phenotype.