Polycystic Kidney Disease Concepts

Front

What is Polycystic Kidney Disease (PKD)?

Back

A genetic disorder characterized by the growth of numerous cysts in the kidneys, leading to kidney enlargement and impaired function.

Front

What are the two main types of PKD?

Back

Autosomal Dominant PKD (ADPKD) and Autosomal Recessive PKD (ARPKD).

Front

When is Autosomal Recessive PKD usually identified?

Back

Prenatally.

Front

What is the primary treatment for PKD?

Back

Kidney transplant and dialysis.

Front

What protein is mutated in PKD?

Back

Polycystin-1.

Front

What is a characteristic feature of PKD?

Back

Fluid-filled cysts in the kidneys.

Front

What is the FDA approved medication to manage PKD?

Back

Tolvaptan.

Front

What is the inheritance pattern of Autosomal Dominant PKD?

Back

It is inherited in an autosomal dominant manner, meaning only one copy of the mutated gene is needed to cause the disease.

Front

What are common symptoms of PKD?

Back

High blood pressure, back or side pain, headaches, and frequent urination.

Front

How does PKD affect kidney function over time?

Back

It leads to progressive loss of kidney function, potentially resulting in kidney failure.