Seizure Continuum Flashcard

Front

Which of the following characteristics is more characteristic of atypical absence seizures than typical absence seizures? eyelid fluttering, head nodding, oral automatisms, prominent alteration in tone, rapid recovery to baseline

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prominent alteration in tone

Front

A 55-year-old woman with relapsed large B-cell lymphoma develops verbal fluency impairment 6 days after chimeric antigen receptor T-cell infusion. Routine EEG demonstrates frontal intermittent rhythmic delta activity. Which diagnosis is most likely?

Back

toxic encephalopathy

Front

Which imaging technique best demonstrates a hypometabolic area associated with the seizure-onset zone in lesion-negative focal epilepsy? Options: fludeoxyglucose positron emission tomography (FDG-PET), functional MRI, ictal single-photon emission computed tomography (SPECT), interictal SPECT, magnetoencephalography (MEG)

Back

fludeoxyglucose positron emission tomography (FDG-PET)

Front

Which of the following genetic abnormalities underlies many self-limited epilepsies in neonates and infants?
epigenetic modifications,
inborn error of metabolism,
ion channel disorders,
mitochondrial disease,
trisomy

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ion channel disorders

Front

Which of the following recently approved antiseizure medications is indicated for the treatment of focal seizures in adults? cannabidiol, cenobamate, fenfluramine, ganaxolone, stiripentol

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cenobamate

Front

A 13-year-old boy with a 10-year history of drug-resistant focal motor seizures has a large area of encephalomalacia in the right middle cerebral artery territory and left-sided spastic hemiparesis. What is the appropriate surgical intervention? Options: corpus callosotomy, deep brain stimulation of the anterior nucleus of the thalamus, functional hemispherectomy, resection of areas of encephalomalacia, responsive neurostimulation anterior and posterior to the encephalomalacia.

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functional hemispherectomy

Front

Which of the following antiseizure medications decreases progestin levels but not estrogen levels?
Options: carbamazepine, clobazam, oxcarbazepine, perampanel, topiramate

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perampanel

Front

Which selective serotonin reuptake inhibitor (SSRI) is preferred in the treatment of moderate to severe depression in people with epilepsy due to a low risk of interacting with antiseizure medications? Options: citalopram, fluoxetine, fluvoxamine, paroxetine, vilazodone

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citalopram

Front

A 60-year-old male with a history of focal epilepsy is in the ED with a breakthrough seizure. He is on Depakote 1000mg ER BID, compliant, with a Val level of 80. Which medication has the strongest evidence for synergistic use with Valproate? Options: Carbamazepine, Lamotrigine, Phenytoin, Topiramate

Back

Lamotrigine

Front

A 70-year-old patient, known epileptic and is on a medication “X”, which is a drug where as the serum concentration increases, it reaches a point where the half life starts increasing. Hence, increasing its dose, disproportionately increases its serum levels. Which of the following could be “X”? Levetiracetam, Lacosamide, Oxcarbazepine, Phenytoin?

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Phenytoin