Revatio Mechanism and Counseling Points

Front

What year was Revatio approved?

Back

2005

Front

What is the mechanism of action of Revatio?

Back

Inhibits phosphodiesterase-5, increasing cGMP and causing pulmonary vasodilation

Front

Which of the following is an important adverse effect of sildenafil to monitor for? Hypotension, Weight gain, Hyperglycemia, Constipation

Back

Hypotension

Front

Which of the following is an appropriate counseling point for a patient taking Revatio?

Back

Report sudden loss of vision

Front

Which of the following best explains why strong CYP3A4 inhibitors affect sildenafil levels? Options: Sildenafil is primarily eliminated renally through active secretion, Sildenafil has no hepatic metabolism, Sildenafil is metabolized by CYP3A4, so inhibitors increase drug concentration, Sildenafil induces CYP3A4, reducing its own clearance

Back

Sildenafil is metabolized by CYP3A4, so inhibitors increase drug concentration

Front

Which patient would be contraindicated from receiving sildenafil? A patient with seasonal allergies, A patient taking an SSRI, A patient with mild GERD, A patient taking a nitrate for chest pain

Back

A patient taking a nitrate for chest pain