Medicine Review

Medicine Review

Multiple Choice

1. Drug disposition commences with which of the following pharmacokinetic processes

• A. Absorption

• B. Distribution

• C. Metabolism

• D. Excretion

Multiple Choice

Drug Elimination commences with which of the following pharmacokinetic processes

• A. Absorption

• B. Distribution

• C. Metabolism

• D. Excretion

Multiple Choice

True of Bioavailability

• A. Rate and extent of drug distribution

• B. Refers to the amount of drug in the blood stream

• C. Rate and extent of blood clearance

• D. 10% only for IM administered drugs

Multiple Choice

A 47 year old patient ingested 24 tablets of aspirin and presents with hepatic encephalopathy. one of the management is to alkalinize the blood through IV NaHCO3. what is the basis of this management?

• A. NaHCO3 traps aspirin in the ionized form

• B. NaHCO3 will neutralize the free aspirin in the systemic circulation

• C. NaHCO3 will neutralize the fraction protein - bound aspirin thus decreasing its toxicity

• D. NaHCO3 induces the CY450 enzyme in the hepatocytes thus accelerating the elimination of toxin

Multiple Choice

In a patient presenting with pneumonia with chest x-ray positive of hazy infiltrates and pneumatoceles, which drug is least likely effective?

• A. Ampicillin - Sulbactam

• B. Piperacellin

• C. Cephalexin

• D. Penicillin G.

Multiple Choice

a 34 year old male presented with EEG changes , seizure and nystagmus accompanied by vomiting and diarrhea after being infused with an antibiotic for his pneumonia. which of the following is the most likely cost?

• A. Streptomycin

• B. Ceptriaxone

• C. Imipenem + Cilostatin

• D. Penicillin G.

Multiple Choice

What is the preferred reliever across all steps in the stepwise approach in asthma management?

• A. LABA

• B. SABA p.r.n

• C. Methylxanthine

• D. ICS + Formoterol

Multiple Choice

Which of the following drugs has blue - green color blindness as one of its adverse effect?

• A. Sildenafil

• B. Ethambutol

• C. Penicillin

• D. Gabapentin

Multiple Choice

Methotrexate is an inhibitor of which of the following enzyme?

• A. Ribonucleotide Reductase

• B. Xanthine Oxidase

• C. Thymidylate Synthase

• D. Dihydrofolate Reductase

Multiple Choice

Which one is correct concerning purine and pyrimidine metabolism?

• A. Purine degrades CO2 and H2O

• B. Pyrimidines, when degraded yield uric acid

• C. Purine cannot be degraded to generate energy

• D. Excess pyrimidine degradation can lead to gout

Multiple Choice

In analyzing a sample of double stranded DNA, it has been determined that the molar amount of adenosine is 20%. given this information, what is the content of cytidine?

• A. 30%

• B. 40%

• C. 10%

• D. 20%

Multiple Choice

You are examining a 7 year old boy who exhibits delayed motor development , over exaggerated reflexes and spasticity . in addition , the boy has a tendency to chew his lips and fingers often causing tissue damage and bleeding. He also has a painful , swollen and inflamed joints. the most likely diagnosis in this case is lesch-nyhan syndrome. Which of the following compounds would be expected to be elevated in the urine of the patient?

• A. Xanthine

• B. Guanine

• C. Uric Acid

• D. Hypoxanthine

Multiple Choice

Lyxose is an example of an?

• A. Aldopentose

• B. Aldohexose

• C. Ketopentose

• D. Ketohexose

Multiple Choice

A 19 year old female rushed to the ER, febrile , hypotensive with scarlatiniform rash, with areas of desquamation in her arms which were insignificant. She has abdominal pain and loose bowel movement since yesterday. She is on her day 4 of menses and uses tampons for the 1st time. She improved and was discharged. what is the most likely diagnosis?

• A. Scarlet Fever

• B. Scalded Skin Syndrome

• C. Toxic Shock Syndrome

• D. Food Poisoning

Multiple Choice

In the previous case , what is the pathophysiologic mechanism that is important in the progression of clinical manifestation?

• A. Exfoliation of the skin cleaves desmoglein

• B. presence of TSST - 1 , a super antigen in the systemic circulation

• C. Consumption Coagulopathy

• D. Ingestion of heat stablle toxin

Multiple Choice

In the previous case , which of the following is correct regarding the causetive agent?

• A. Catalase (-), Coagulase (+)

• B. Gram (+) cocci in tetrads

• C. Possesses penicillinase enzyme

• D. Optochin and Bacitracin sensitive

Multiple Choice

An 8 year old boy from Bulacan presents with fever, cough and respiratory distress. In the ER patient was unstable and in tripod position . CXR showed hazy infiltrates in bilateral lower lung fields with area of cystic lucency in the middle lobe. AFB sputum smear is negative. What is the most likely the causative agent?

• A. Streptococcus Pneumoniae

• B. Klebsiella Pneumoniae

• C. Legionella Pneumophilla

• D. Staphylococcus Aureus

Multiple Choice

In the previous case, which drug is the least likely to be effective?

• A. Ampicillin - Sulbactam

• B. Piperacillin

• C. Cephalexin

• D. Penicillin G

Multiple Choice

Which of the following drugs have coverage for the causative agent of "Whoolsorter's Disease" ?

• A. Penicillin and Ciprofloxacin

• B. Monoclonal Antibody

• C. Doxycycline

• D. All of the Above

Multiple Choice

According to CDC abd WHO guidelines , in a patient sustaining a cat bite below the angle of the mandible , 3 mm in size with non spontaneous bleeding. which of the following should be given? (PMH : no previous vaccination)

• A. Rabies Vaccine + Rabies Ig

• B. Rabies Vaccine + tetanus vaccine

• C. Rabies Vaccine + Tetanus Vaccine +TIg

• D. None of the above

Multiple Choice

According to CDC abd WHO guidelines , in a patient sustaining a cat bite below the angle of the mandible , 3 mm in size with non spontaneous bleeding. which of the following should be given? (PMH : no previous vaccination)

• A. Rabies Vaccine + Rabies Ig

• B. Rabies Vaccine + tetanus vaccine

• C. Rabies Vaccine + Tetanus Vaccine +TIg

• D. None of the above