MDD & Duxead Module - Assessment - 2

DUXEAD

Module & Assessment - 2

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(MDD & Duloxetine​ USPs)

Cerebris - Mankind Specialities - Therapy Training

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Open Ended

Your Employee Code is

Open Ended

Your region is ______

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• ​Unexplained PPS approximately 2/3rd  of depressed patients.

• UPPS are a predictor of a poor response to treatment and a more chronic course of depression.

• Pain, in the course of depression, also has a negative impact on functioning and quality of life.

• In Depression, Abnormal function of brain networks involved in the regulation of both emotions and pain -leading to the presence of UPPS.

• Insufficiency of descending serotonin and noradrenaline pathways and abnormal activation of proinflammatory cytokines and substance P results in Painful physical symptoms

​Painful Physical Symptoms (PPS)

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​What is Fibromyalgia?

​Fibromyalgia is a disorder characterized by widespread musculoskeletal pain accompanied by fatigue, sleep, memory and mood issues

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Patients also experience a range of other somatic complaints that may include irritable bowel syndrome, cognitive impairment, headache, anxiety and depression, among others​

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Duloxetine have been demonstrated to improve pain, Fibromyalgia symptoms, anxiety and depression, hence is a reasonable choice for many patients with FM.​

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Multiple Choice

Duloxetine is _________

• Noradrenaline specific Reuptake inhibitor

• Selective Serotonin Reuptake Inhibitor (SSRI)

• Tricycic Antidepressantt

• Selective Serotonin and Norepinephrine Reuptake inhibitor

Multiple Choice

Duloxetine is beneficial in ________

• Resolving mood symptoms in MDD

• Improvises Cognitive function

• Treats coreemotional and Painful physical symptoms

• All of the above

Multiple Choice

Duloxetine has no significant affinity for cholinergic, histaminergic, dopaminergic, opioid, glutamate, GABA, cholinergic and adrenergic receptors and does not inhibit monoamine oxidase. State TRUE or FALSE

• TRUE

• FALSE

• ​Duloxetine, is a potent dual inhibitor of both 5-HT and NE reuptake (SNRI).

  Has nosignificant affinity for cholinergic, histaminergic, dopaminergic, opioid, glutamate, GABA, cholinergic and adrenergic receptors and does not inhibit monoamine oxidase.

• ​​Efficacy of duloxetine for the acute treatment of MDD is well established

• ​​Improved somatic symptoms, particularly painful symptoms which contributes to significantly improved remission rate -improvement as early as 1 -2 weeks

• ​Significant improvement in reducing the symptoms of depression ( HAM-D17, anxious symptoms as measured by the HAM-A, and quality of life )

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DUXEAD - ​Duloxetine Benefits

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Multiple Choice

Starting dose of Duloxetine in MDD is __________ /day generally in 2 divided dose

• 10 to 20 mg / day

• 40 to 60- mg /day

• 30 mg / day

Multiple Choice

Maximum dose of Duloxetine in MDD is_______mg / day

• 80

• 60

• 100

• 120

Multiple Choice

As per recommendation - In Fibromyalgia & Chronic Musciloskeletal Pain the starting dose of Dose of duloxetine is ______mg /day and maximum dose is ___mg / day

• Starting - 50 mg / day & Max - 60 mg / day

• Starting - 10 mg / day & Max - 30 mg / day

• Starting - 30 mg / day & Max - 60 mg / day

• Starting - 60 mg / day & Max - 120 mg / day

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Multiple Choice

Duxead comes with DECO technology which means _________

• Differentiate & Dissolve Enteron Covered tablets

• Different & Dual Enteric COted tablets

• Diffuse & Dissolve Enteric COated tablets

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Multiple Choice

In fibromyalgia, Diabetic peripheral neuropathy and Chronic Pain Duloxetine improves Painful physical symptoms & improves attention based task and sensory motor performance. (The above Duxead communication is specific to ____Dr Speciality)

• Psychiatry

• Neurologist

Multiple Select

DECO technology offers Dual Action that is ___________ (Tick two correct options)

• Rapid onset of action

• Sustained onset of action

• Diffuses and dissolves in intestine

• Diffuses and dissolves in Stomach

Multiple Select

DECO technology offers Dual Benefits that is ___________ (Tick two correct options)

• Reduces nausea

• Reduces Absorption of food

• Prevents gastric Motility

• Prevents gastric irritation

​Thank - you

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