Chemical reaction of amine

Chemical reaction of amine

By ALICE Moe

​Preparation of Amine

• Alkylation of ammonia

• Reduction of nitrile

• Reduction of amide

Multiple Choice

? + 2NH₃ /ethanol/reflux $$\rightarrow$$   CH₃CH₂NH₂ + NH₄Br

• CH₃Br

• CH₃CH₂Br

• CH₃CH₂OH

• CH₃OH

Multiple Choice

? + LiAlH₄/H⁺ $$\rightarrow$$  C₆H₅CH₂NH₂

• C₆H₅CH₂CN

• C₆H₅CN

• C₆H₅OH

• C₆H₅CH₂OH

Multiple Choice

? + LiAlH₄/H⁺ $$\rightarrow$$  CH₃CH₂NH₂ + H₂O

• CH₃CONH₂

• CH₃CH₂OH

• CH₃CH₂Cl

• CH₃CH₂CONH₂

​Chemical reaction of aliphatic amine

• Neutralisation: with acid HX → ammonium salt

• With acyl chloride→ amide

• Diazotization: NaNO₂ + HCl/0-5 ^oC → ROH + N₂

​SQ 1 (1999)

SQ 2 (2001)​

​Reaction of phenylamine

• Bromination: Br₂(aq) → white precipitate

• Coupling reaction:

  • 1. NaNO₂, HCl/0-5^oC

  • 2. Phenol in NaOH/0-5^oC

​SQ 3(2006)

SQ 4(2008)​