IMMU 183-Final Exam Review

LO7-LO8 Review

Multiple Choice

Which of the following is associated with anaphylaxis?

• Buildup of IgE on mast cells

• Activation of complement

• Increase in cytotoxic T cells

• Large amount of circulating IgG

Multiple Choice

In Type I Hypersensitivity, what occurs when two adjacent IgE molecules cross link?

• Chemotaxis of neutrophils

• Hemolysis

• Release of preformed mediators

• Deposition of immune complexes

Multiple Choice

What is the immune mechanism involved in type III hypersensitivity reactions?

• Production of IgE in response to allergen

• Deposition of immune complexes occurs

• Cytotoxic reaction involving IgG and/or IgM

• Sensitized T cells produce delayed cell mediated response

Multiple Choice

Reaction to poison ivy is which type of hypersensitivity?

• Type I

• Type II

• Type III

• Type IV

Multiple Choice

All of the hypersensitivity responses have which of the following in common?

• Involvement of antibody

• Asymptomatic sensitization phase

• Release of histamine

• Activation of macrophages against a pathogen

Multiple Choice

Which of the following is a preformed mediators that is released during the activation phase of a type I hypersensitivity response?

• Leukotriene

• Prostaglandin

• Histamine

• Platelet Activating Factor (PAF)

Multiple Choice

Which condition would result in HDFN?

• Buildup of IgE on mother's cells

• Sensitization of cytotoxic T cells

• Exposure to antigens found on both mother and baby red cells

• Prior exposure of mother to foreign red cell antigen

Multiple Choice

What is the function of histamine as a preformed mediator?

• Attracts eosinophils to the area

• Contraction of smooth muscle in bronchioles and intestines

• Causes platelet aggregation

• Attracts neutrophils to the area

Multiple Choice

Autoimmune hemolytic anemia occurs when an individual forms antibodies against their own red blood cells. What type of hypersensitivity does this describe?

• Type IV

• Type III

• Type II

• Type I

Multiple Choice

Which of the following are the genes associated with MHC class II?

• CD2, CD3, CD8

• HLA-C

• HLA-DR

• HLA-Q

Multiple Choice

Which of the following can lead to a loss of self-tolerance?

• Deletion of self reactive T cells

• No change to self antigens after exposure to radiation

• Bacteria with antigens that are very different from self antigens

• Failure to delete self reactive B cells

Multiple Choice

During development of a tumor, cancer cells may produce large amounts of this type of antigen normally produced by the fetus:

• Tumor specific antigens

• Virus induced tumor antigens

• Genome encoded tumor antigens

• Oncofetal antigens

Multiple Choice

Most cancers have all of the following characteristics EXCEPT:

• Mature cells

• Disorganized behaviour

• Immature cells

• An uncontrolled growth of abnormal cells

Multiple Choice

Oncogenes result from single point mutations of protooncogenes and have this type of tumor associated antigen:

• Tumor Specific Antigen

• Virus Induced Tumor Antigen

• Genome Encoded Tumor Antigen

• Oncofetal Antigen

Multiple Choice

Which of the following describes a secondary immunodeficiency?

• Present at birth

• Hereditary immunodeficiency

• Acquired after birth

• Defect in development of immune system

Multiple Choice

Thymic hypoplasia (DiGeorge Syndrome) occurs when the thymus does not develop properly and T lymphocytes are decreased.

• True

• False

Multiple Choice

Which of the following immunodeficiencies involves dysfunction in the complement regulator C1 inhibitor?

• Hereditary Angiodema

• Wiskott-Aldrich Syndrome

• Selective IgA Deficiency

• Nezelof's Syndrome