Therapeutic Studies & Systematic Review/Meta-analysis

​Therapeutic Studies &Systematic Review/Meta-analysis

RAID433: Critical Thinking in Medicine

Department of Clinical Epidemiology & Biostatistics

Faculty of Medicine Ramathibodi Hospital

​​Scope of lecture

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•Systematic review versus traditional review

•Methods of conducting systematic review

•Meta-analysis

•Critical appraisal of systematic review and meta-analysis

Systematic review

•Types of clinical trial design

•Process of clinical trial

•Basic calculation from therapeutic studies

•Critical appraisal of therapeutic studies

Therapeutic Studies & Clinical Trials

What is “Systematic Review”

•A review of a particular subject undertaken in such a systematic way that risk of bias is reduced.

•Systemic reviews have explicit, scientific, and comprehensive descriptions of their objectives and methods.

Subject | Subject

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Multiple Choice

What is the phase I for Clinical Trial?

• Clinical pharmacology / toxicology, dose fining, safety, perfection of technique

• Initial clinical investigation for treatment effect, pilot study

• Full-scale evaluation of treatment effect (efficacy)*

• Post-market surveillance (effectiveness)

Multiple Choice

What is the advantage of Randomized Allocation or Randomization?

• Imbalance of number of participants in each group

• Imbalance of number of participants with and without confounding factors

• Less number of participants – higher risk of imbalance

• Each assignment is completely unpredictable

Multiple Choice

What is the disadvantages of RCT over Observational Study Design?

• Controls similar to exposure case

• Can’t evaluate potentially harmful exposure

• Reduce information bias

• Detect small to moderate effect