Antiinfective antiinflammatory

Match

Match the following

• Ciprofloxacin

• Vancomycin

• Tetracycline

Inhibit DNA gyrase

Inhibit peptidoglycan cross-linking

Inhibit protein synthesis

• Inhibit DNA gyrase

• Inhibit peptidoglycan cross-linking

• Inhibit protein synthesis

Match

Match the following antibiotics to its common beta-lactamase inhibitors

• Amoxyxillin

• Piperacillin

• Ampicillin

clavulinic acid

tazobactam

sulbactam

• clavulinic acid

• tazobactam

• sulbactam

​https://www.youtube.com/shorts/PlAhOR9pylI

Multiple Choice

Tobramycin elicits its pharmacological action by

• inhibiting 30S ribosome subunit

• inhibiting 50S ribosome subunit

• by inhibiting DNA topoisomerase

• by inhibiting DNA gyrase

Fill in the Blanks

Sulfonamides and trimetoprim individually are bacteriostatic antibiotics. When combined, they become bactericidal because of

action

Multiple Choice

What is the primary mechanism of action of Amphotericin B in the treatment of fungal infections?

• Inhibits the synthesis of nucleic acids within fungal cells.

• Prevents the formation of fungal cell walls by blocking enzyme activity

• Binds to ergosterol in fungal cell membranes, increasing permeability

• Disrupts fungal metabolism by inhibiting key enzymatic pathways

Multiple Choice

Acyclovir is a nucleoside analogue

• True

• False

Multiple Choice

Acyclovir is used to treat herpes simplex keratitis resistant to foscarnet

• True

• False

Multiple Choice

A 32-year-old contact lens wearer presents with red, painful eyes and blurred vision, diagnosed with bacterial keratitis. Despite treatment with topical moxifloxacin, symptoms persist after three days, raising concerns about antibiotic resistance.
Moxifloxacin resistance in keratitis is primarily caused by bacterial production of β-lactamase enzymes that degrade the antibiotic.

• True

• False

Multiple Choice

A 32-year-old contact lens wearer presents with red, painful eyes and blurred vision, diagnosed with bacterial keratitis. Despite treatment with topical moxifloxacin, symptoms persist after three days, raising concerns about antibiotic resistance.
Mutation in the quinolone resistance-determining regions (QRDRs) of DNA gyrase can hinder moxifloxacin from binding effectively, leading to resistance in keratitis infections.

• True

• False

Multiple Select

NSAIDs like ketorolac are suitable agents to be used post-surgically because

• They can be used for treating infections

• They have anti-inflammatory action

• They have analgesic action

Multiple Choice

Dexamethasone exerts its anti-inflammatory action by

• inhibition of leucotriene

• inhibition of prostaglandin (PGE)

• inhibition of phospholipase A2 enzyme

• inhibition of phospholipase A2 transcription

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