Cell Cycle Disruptions

​Checkpoints and Cancer

Cell Cycle Checkpoints, factors that signal cell cycle, and cancer​

Understand the checkpoints that regulate cell cycle, and the unregulated cancer cells. ​

​I Will...

Review the cell cycle, learn about the checkpoints that regulate cell cycle, and unregulated cancer cells.

​We Will...

​The Win for the Day...

Match

Match the following

• cell growth

• DNA Replicates

• Interphase

• M Phase

• division of nucleus

G₁

S

G₁, S, G₂

Cell Division

Mitosis

• G₁

• S

• G₁, S, G₂

• Cell Division

• Mitosis

Multiple Choice

In which phase of a cell’s life cycle will the cell have two copies of its DNA?

• Beginning of G₁

• Beginning of S

• End of S

• End of M

Reorder

Put the stages of the cell cycle in order from Interphase to M Phase

• G₁

• S

• G₂

• Mitosis

• Cytokinesis

1

2

3

4

5

• 1
• 2
• 3
• 4
• 5

External - physical and chemical signals​

• Physical: cell to cell touch, cells touch and stop dividing

• ​Chemical: growth factors that signal cell division

​

​Factors that Regulate Cell Cycle

​

Internal - signaled by binding of external factors to their receptors

• Kinases: enzyme transfers phosphate groups from one molecule to specific target molecule.

• ​Cyclines: group of proteins that are rapidly made and destroyed at certain points in cell cycle.

​

​Factors that Regulate Cell Cycle

​

Understand the checkpoints that regulate cell cycle, and the unregulated cancer cells. ​

​I Will...

Review the cell cycle, learn about the checkpoints that regulate cell cycle, and unregulated cancer cells.

​We Will...

​The Win for the Day...

To prevent the compromised cell from continuing to divide, internal control mechanisms operate at 4 cell cycle checkpoints:

1. G1 Phase

2. S Phase

3. G2 Phase

4. M Phase

​Occurs at the end of each phase

​Checkpoints

​

G1 Checkpoint:

​

​Checks for healthy DNA and if there are enough resources for division

​Occurs at the end of each phase

​Checkpoints

​

S Phase:

​

​Checking for errors in replicated DNA

​Occurs at the end of each phase

​Checkpoints

​

G2 Phase

​

​Rechecking for DNA damage, ensuring that chromosome set is complete and that there are enough cell components for division

​Occurs at the end of each phase

​Checkpoints

​

M Phase:

​

Checking to see if all chromosomes are attached to mitotic spindle fibers extending from the centriole.

​

​

​

​Occurs at the end of each phase

​Checkpoints

​

​If there are any errors that cannot be corrected at each checkpoint, the cell undergoes apoptosis - programmed cell death, appempt to avoid mutations/cancer

​

​

Important!​

​

Multiple Choice

These are important points in the cell cycle that look for errors and stop the process if errors are detected to prevent changed cells

• Checkpoints

• Cell Cycle

• Apoptosis

• Interphase

Multiple Choice

If a cell cannot repair damage to its DNA, what process does the cell enter normally?

• M Phase

• Apoptosis

• Mitosis

• Meiosis

Understand the checkpoints that regulate cell cycle, and the unregulated cancer cells. ​

​I Will...

Review the cell cycle, learn about the checkpoints that regulate cell cycle, and unregulated cancer cells.

​We Will...

​The Win for the Day...

Unregulated and uncontrolled cell growth

Cancer tumors are either:

• benign (not dangerous)

• malignant​ (dangerous)

​

Cancer occurs when tumor suppressor genes do not work properly to prevent uncontrolled cell growth.

​

​Cancer is...

​

Multiple Choice

Cancer is described as _________________ cell growth.

• unregulated and uncontrolled

• regulated and controlled

• slow and steady

• checks and balances

​Exit Ticket

Quizezz assignment

"Cancer and Cell Cycle Assignment"