Mutations and Gene Expression

Unit 4 Day 9- Mutations

By jack morgan

Multiple Choice

DNA is always replicated from...

• 5' end to 3' end

• 3' end to 5' end

• 1' end to 3' end

• 3' end to 1' end

Multiple Choice

In Translation, the START codon is...

• GUA

• UAG

• AUG

• UGA

mutation- any change to the nucleotide sequence of

a cells DNA ​

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What are mutations, really?​

​

​TRAITS

Transcription​

Translation​

Point Mutations (aka substitution)

​ - mutation affect only one or a few nucleotides on a DNA sequence

​

Frameshift Mutations​ (aka deletion and replication)

• ​a mutation due to insertion or deletion of nucleotides which change the way the code is "read"

Mutations within a gene can be divided into 2 categories:​

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Open Ended

Discuss with your group: Could a mutation occur and have no effect on the expression of the gene? Why or Why Not?

This can occur because there is more than one codon for most amino acids​

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When a mutation has no effect on gene expression, it is known as a

silent mutation​

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Open Ended

Which type of mutation is more likely to have an effect on gene expression, point or frameshift? Why?

The most "famous" point mutation is the cause of Sickle Cell Anemia​

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​A single nucleotide out of place can cause all of this

Any Questions?​