2 regulatory and 2 catalytic subunits

1 regulatory and 2 catalytic subunits

2 regulatory and 1 catalytic subunits

1 regulatory and 1 catalytic subunits

What directly causes activation of PKA?

cAMP binding to regulatory subunit of PKA and causing conformational change and dissociation of subunits

Effector molecule binding and causing a conformational change in GPCR

Phosphorylase kinase phosphorylating PKA

Activated adenylyl cyclase binding to regulatory subunit of PKA

Which of the following is NOT an example of a part of the cAMP pathway?

Paracrine signaling activation of GPCR

Activation of gene transcription

Which of the following is the correct pathway?

cAMP -> PKA -> Phosphorylase Kinase -> Glycogen Kinase -> Glycogen Breakdown

cAMP -> Phosphorylase Kinase -> PKA -> Glycogen Kinase -> Glycogen Breakdown

cAMP->PKA-> Phosphorylase Kinase->Nucleus-> Transcription

cAMP-> Phosphorylase Kinase->Nucleus-> Transcription

Which pathway is correct?

Adrenaline, GPCR, adenylyl cyclase, cAMP, PKA, nucleus, transcription activation

Adrenaline, GPCR, cAMP, adenylyl cyclase, PKA, nucleus, transcription activation

Adrenaline, GPCR, adenylyl cyclase, PKA, cAMP, nucleus, transcription activation

Adrenaline, GPCR, cAMP, adenylyl cyclase, PKA, nucleus, translation activation

How does PKA activate transcription?

By phosphorylating a specific transcription regulator

By silencing specific transcription regulators

By binding to a specific transcription regulator

Cyclic AMP dependent protein kinase

Adenylyl cyclase dependent protein kinase

Which of the following is the correct pathway?

Catalytic PKA subunit, nucleus, phosphorylation of CREB, CREB recruits CBP, CREB/CBP binding to CRE, translation

Catalytic PKA subunit, nucleus, phosphorylation of CREB, CREB recruits CRE, CREB/CRE binding to CBP, translation

Catalytic PKA subunit, nucleus, phosphorylation of CBP, CBP recruits CREB, CREB/CBP binding to CRE, translation

Regulatory PKA subunit, nucleus, phosphorylation of CREB, CREB recruits CBP, CREB/CBP binding to CRE, translation

Which of the following is TRUE.

CRE is a cis regulatory sequence

CBP, once phosphorylated, recruits CREB

CREB/CRE stimulates translation of target proteins

PKA phosphorylates a sing threonine on CREB

Adrenaline to the heart stimulates...

Increased heart rate and force of contraction

Decreased heart rate and force of contraction

Increased heart rate and decreased force of contraction

Decreased heart rate and increased force of contraction

A receptor and some of the intracellular signaling proteins it activates in sequence are pre-assembled into a signaling complex on the inactive receptor is an example of...

Pre-formed signaling complex on a scaffold protein

Assembly of signaling complex on an activated receptor

Assembly of signaling complex on phosphoinositide

A signaling complex assembles transiently on the receptor only after the EC signal molecule activate the receptor is an example of...

Assembly of signaling complex on an activated receptor

Pre-formed signaling complex on a scaffold protein

Assembly of signaling complex on phosphoinositide

Activation of a receptor leads to increased phosphorylation of specific phospholipids in the adjacent PM is an example of..

Assembly of signaling complex on phosphoinositide

Pre-formed signaling complex on a scaffold protein

Assembly of signaling complex on an activated receptor

cAMP Pathway

Biology

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MULTIPLE CHOICE QUESTION

2 mins • 1 pt

What produces cAMP?

Adenylyl cyclase

Adenine cyclase

AMPase

ADPase

MULTIPLE CHOICE QUESTION

2 mins • 1 pt

What activates adenylyl cyclase?

Alpha subunit exchange of GDP for GTP

GTPase phosphorylation on alpha subunit

Activated beta/gamma complex

Protein kinase phospharylation

MULTIPLE CHOICE QUESTION

2 mins • 1 pt

What is converted into cAMP?

ATP

cATP

ADP

cADP

MULTIPLE CHOICE QUESTION

2 mins • 1 pt

True or False. cAMP is considered a primary messenger.

False

True

MULTIPLE CHOICE QUESTION

2 mins • 1 pt

What signaling molecule causes cAMP production in skeletal muscles?

Adrenaline

Norepinephrine

Acetylcholine

Cortisol

MULTIPLE CHOICE QUESTION

2 mins • 1 pt

Production of cAMP in skeletal muscle causes...

breakdown of glycogen maximizing the amount of glucose available for fuel

breakdown of glucose maximizing the amount of glycogen available for fuel

breakdown of glycogen minimizing the amount of glucose available for fuel

breakdown of glucose minimizing the amount of glycogen available for fuel

MULTIPLE CHOICE QUESTION

15 mins • 1 pt

Which of the following statements is TRUE.

cAMP binds to inactive catalytic subunit of PKA to activate it

cAMP binds to regulatory subunit of PKA to activate it

cAMP binds to both regulatory and catalytic subunit of PKA to activate it

cAMP binds to alpha subunit of PKA to activate it

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cAMP Pathway

What produces cAMP?

What activates adenylyl cyclase?

What is converted into cAMP?

True or False. cAMP is considered a primary messenger.

What signaling molecule causes cAMP production in skeletal muscles?

Production of cAMP in skeletal muscle causes...

Which of the following statements is TRUE.

PKA consists of...

What directly causes activation of PKA?

True or False. PKA activation can cause activation in gene transcription.

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