[54] Neurodegeneration 1

The basal ganglia contain...

• dopaminergic neurons
• GABAergic neurons
• excitatory neurons
• cholinergic neurons

The principal afferent impulses to the basal ganglia from the cerebral cortex and thalamus use...

• glutamate
• acetylcholine
• GABA
• dopamine

Each spiny neuron receives only 1 – 2 synapses from an individual cortical neuron. There is axodendritic ...

• convergence
• divergence

A dopaminergic nerve terminal synapses with the spine at the base and acts to...

• regulate cortical input
• increase cortical input
• decrease cortical input

The HD gene (ITI5) codes for ‘huntingtin’ protein- it's on chromosome ... and is a ... repeat

• 4 ; CAG
• 17 ; CAT
• 21 ; CAG
• 17: CAG

The pathologic feature of HD is...

• inclusion bodies in striatal neurons
• SNCA in dopaminergic neurons
• extracellular plaques
• intracellular neuropil threads

Is HD characterised by hyperkinetic movements?

• No- 1-hyperkinetic 2-hypokinetic
• Yes- always hyperkinetic
• No- always hypokinetic
• No- 1- hypokinetic 2- hyperkinetic

In PD around 10% of people are affected through family history. The GWAS variation of SNCA is on chromosome...

• 4 like Huntington's
• 17 like FTD
• 21 like trisomy 21

Why does deep brain stimulation to subthalamic nucleus improve PD symptoms in patients?

• decreases its relative activity
• increases its relative activity
• increases the direct pathway
• decreases its indirect pathway