Cell Differentiation

Cell Differentiation

9th - 12th Grade

10 Qs

quiz-placeholder

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Cell Differentiation

Cell Differentiation

Assessment

Quiz

Biology

9th - 12th Grade

Practice Problem

Medium

NGSS
HS-LS1-4, MS-LS3-2, MS-LS3-1

+4

Standards-aligned

Created by

Susan Campeau

Used 812+ times

FREE Resource

About this resource

This quiz focuses on cell differentiation and specialization, which is a fundamental concept in high school biology appropriate for grades 9-12. The questions assess students' understanding of how genetically identical cells develop into specialized cell types with distinct structures and functions. Students need to grasp that while all somatic cells contain the same DNA, different genes are expressed in different cell types through regulatory mechanisms that turn specific genes on or off. The quiz evaluates comprehension of key processes including fertilization, the role of stem cells as precursors to specialized cells, and how chemical signals from the organism or environment control gene expression patterns. Students must understand that cell differentiation is driven by selective gene activation rather than changes to the actual DNA sequence, and that this specialization ultimately serves the organism's need to maintain homeostasis through diverse cellular functions. Created by Susan Campeau, a Biology teacher in the United States who teaches grades 9-12. This quiz serves as an excellent formative assessment tool to gauge student understanding of cellular differentiation before moving into more advanced topics in developmental biology or genetics. Teachers can use this as a warm-up activity to activate prior knowledge, as guided practice during instruction, or as homework to reinforce learning after lessons on cell specialization. The quiz effectively supports review sessions before unit tests and helps identify misconceptions about gene expression and cellular development. This assessment aligns with Next Generation Science Standards HS-LS1-4, which requires students to use representations to model how DNA provides instructions for synthesizing proteins that determine traits, and supports understanding of how cells become specialized through differential gene expression patterns.

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10 questions

Show all answers

1.

MULTIPLE CHOICE QUESTION

45 sec • 1 pt

All our cells, except sex cells like eggs or sperm, have ___________ DNA

different
similar
exactly the same
half the amount of 

Tags

NGSS.MS-LS3-2

2.

MULTIPLE CHOICE QUESTION

1 min • 1 pt

Media Image

The diagram shows the process of cell specialization from a single stem cell. Which of the following statements is true about the process of specialization.

Specilized cells (blood, skin, nervous etc) cannot be produced from a single stem cell
Specilized cells are produced immediately following fertilization
Even though all the cells in an organism come from one single cell, they can specialize into different cell types
Sincce all the cells in an organism come from one single cell, they must all have the same structure and function

Tags

NGSS.HS-LS1-4

3.

MULTIPLE CHOICE QUESTION

45 sec • 1 pt

In what way is the DNA of a nerve cell different from the DNA of a muscle cell?

The DNA is the same but each cell contains different genes
The DNA is the same but different genes are turned on in each cell
Each cell has its own unique DNA
The DNA is different, but each cell contains the same genes

Tags

NGSS.MS-LS3-1

4.

MULTIPLE CHOICE QUESTION

45 sec • 1 pt

When one sperm cell combines with one egg cell.

Fertilization
Binary Fission
Asexual Reproduction 
Mitosis

Tags

NGSS.HS-LS3-2

NGSS.HS-LS4-2

5.

MULTIPLE CHOICE QUESTION

45 sec • 1 pt

How do stem cells know what type of cells to differentiate into?

The nucleus has instructions to turn some genes on and some genes off
Signals from chemicals in the organism or from the environment determine which genes will be turned on and off
Genes turn on and off randomly
The cell has unique DNA that determines what the cell will become.

Tags

NGSS.HS-LS1-4

6.

MULTIPLE CHOICE QUESTION

1 min • 1 pt

What is cell specialization or differentiation?

The process where unspecialized cells become different in structure and function.
When DNA controls the cell cycle.
The ability of cells to make more cells.
The ability of cells to maintain homeostasis.

Tags

NGSS.HS-LS1-4

7.

MULTIPLE CHOICE QUESTION

45 sec • 1 pt

What is one goal of cellular differentiation/specialization?

To create specialized cells to help organism maintain homeostasis.
To many cells.
To make stem cells
to make single celled organisms

Tags

NGSS.HS-LS1-3

NGSS.HS-LS1-4

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