Lets (thrombin) generate some answers!

Prolongation of the PT and/or aPTT indicates (choose all that apply)

• deficiency of one or more procoagulant factors

• increase in one or more anticoagulant factors

• increase in one or more fibrinolytic factors

• dysfunction of one or more procoagulant factors

• inhibition of one or more procoagulant factors

Peak thrombin concentration in vivo directly affects (choose all that apply)

• amount of platelet activation

• amount of protein C activation

• rate of clot formation

• strength of the fibrin clot meshwork

• resistance of the clot to fibrinolysis

CD61 is a subunit of the platelet receptor that binds (choose all that apply)

• thrombomodulin

• fibrinogen

• collagen

• von Willebrand factor

• thrombin

Which gate contains platelet microparticles

• A

• B

The image represents a thrombogram of two different rat plasma samples. Which of the following may apply to the red tracing compared with the blue? (choose all that apply).

• the red is male versus female (blue)

• the red contains more platelets and platelet microparticles

• the red had inadequate centrifugation

• the red shows less fibrinolysis

• the red has a greater endogenous thrombin potential

The chromogenic anti Factor Xa activity assay measures (choose all that apply)

• the concentration of heparin in plasma

• the concentration of apixaban in plasma

• the patient's factor X activity

• the effect of anticoagulants on patient factor X