PHAR 7401 - Metabolism: Nucleic Acids

When we talk about ATP, how many phosphate groups are attached to the ribose sugar group?

• 1

• 2

• 3

• 4

• 0

The de novo synthesis of nucleotides and the salvage pathways of nucleotides are the same for nucleotide production?

• False

• True

Amino acids are used in the process of purine biosynthesis.

• False

• True

Each individual nucleotide must be synthesized de novo because there interconversion is NOT possible?

• False

• True

Gout, in layman's terms, is a disease caused by the accumulation of a chemical, uric acid, in the joints. This leads to an inflammatory response by the body. Uric acid itself is produced when nucleic acids (DNA/RNA) are broken down. Which of these foods would contain the highest amount of nucleic acids?

• Beef muscle tissue (i.e. a steak) low in cell numbers but high in extracellular matrix content

• Offal meats (i.e. thymus, liver, etc.) high in cell numbers

• Blood sausages made from beef blood that's rich in red blood cells

• Celery salad

• Mixed nuts

The difference between a ribonucleotide and a deoxyribonucleotide is:

• A deoxyribonucleotide has a -H instead of an -OH at C2

• A deoxyribonucleotide has an alpha configuration, while a ribonucleotide has a beta configuration.

• A ribonucleotide has an extra -OH at C4

• A ribonucleotide has more structural flexibility than a deoxyribonucleotide

• A ribonucleotide is a pyranose, while a deoxyribonucleotide is a furanose

Which of the following amino acids are involved in the synthesis of purine nucleotides? Select all that apply.

• Guanine

• Thymine

• Cytosine

• Adenine

Uric acid, which is implicated in the condition called gout is a ____ of nucleotide metabolism.

• Cofactor

• Enzyme

• Waste Product

• Reducing Agent

• None of the Above

The byproducts of purine metabolism are water-soluble and lead to no, if minimal, disease states or symptoms?

• False

• True

The production of PRPP, the precursor molecule for either pyrimidine or purine synthesis, can be allosterically inhibited by high levels of nucleosides.

• False

• True