Sickle cell disease

What causes Sickle Cell Anemia?

• A mutation in the hemoglobin-beta gene found on Chromosome 11.

• A mutation in the the hemoglobin- alpha gene found on Chromosome 12.

• The environment.

• Malaria.

Which characteristic of Sickle Cell Anemia is false?

• Crescent blood cells

• An extra hemoglobin molecule forming the red blood cell.

• Increased white blood cell counts.

• Helps to prevent/fight Malaria

Sickle Cell Disease occurs more frequently around the Equator?

• True

• False

What causes sickle cel around the equator?

• Malaria

• Toxocariasis

• Trypanosomiasis

• Schistosomiasis

How does Sickle Cell Disease impact the everyday life of an individual?

• Acute and chronic complications for the patient

• Sickle Cell patients could have a shorter life span

• Patients could easily be infected by viruses due to a weak immune system.

• All of the above

which amino acids are responsible for the formation of sickle cell disease?

• Glutamic acid to valine

• Valine to glutamic acid

• Cystene to Valine

• Valine to Cystene

Which protein is affected by sickle cell disease?

• hemologbin

• fibrin

• lipase

• pepsin

Valine is...

• a protein that is neutral

• an amino acid that is neutral

• an amino acid that is hydrophobic

• an amino acid that is hydrophilic

• a protein that is hydrophobic

Glutamic acid is...

• a protein that is hydrophlic

• a protein that is hydrophobic

• a protein that is neutral

• an amino acid that is hydrophilic

• an amino acid that is hydrophobic

which of the factors below does not cause the crescent shape of the sickle cells?

• the hydrophobic/ hydrophilic interactions of the swapped amino acids with the internal environment of the body.

• the amino acid chains of the hemoglobin protein became clumped together instead of being spread out.

• the switch from glutamine to valine

• a mutation in the gene that causes a change in the leucine amino acid