PT716A_Day4_021_pilotplantstudy_TD

Semi - Solid dosage form contains

• 2 Phases

• 3 Phases

• 1 Phase

Which of the statements are true for semi - solid dosage form?

• The Active Ingredient is dissolved in one phase

• The Active Ingredient is dispersed in one or both phases

• They create a 3 phase system

The physical Properties on which the semi solid dosage form scale up depends on are -

• Size of dispersed particles

• Interfacial Tension

• Partition Coefficient of AI in the two phases

The most vital factor of drug release in case of semi-solid dosage form is -

• Viscosity

• Density

• Particle size

The effect that SUPAC changes may have on stability of the drug product should be evaluated.

• TRUE

• False

The key parameter of any drug in semi - solid dosage form is -

• efficacy

• LD50

• ED50

______________release rate can reflect the combined effect of physical & chemical parameters.

• In vivo

• In vitro

• Ex vivo

Decrease in droplet/particle size leads to _____________ in degree of dispersion.

• Increase

• Decrease

• No Effect

In typical Manufacturing process, the critical points are -

• Initial separation of one phase system into two phases

• the point at which the active ingredient is added.

Equipments generally used in case of semi solid products -

• Blending Equipment

• Mixing Equipment

• Pressure Filling Equipment