Module 3: Solid Dosage Form (BSP 3A)

Solid dosage forms in which one or more medicinal and inert ingredients are enclosed in a small shell or container usually made of gelatin.

• Tablet

• Capsule

• Creams

• Ointment

The purpose of this operation is to ensure equal distribution of ingredients in order to achieve uniformity.

• Milling

• Screening

• Blending

• Printing

The following are achieved thru granulation, except:

• Make the powder more compressible

• improve the flowability of the powder

• To ensure uniform distribution of API in the powder

• Reduce the particle size of the powder

It moves to fill the die with granules at the same time it retracts to scrapes all excess granulation away from the die cavity.

• Hopper

• Feed shoe

• punches

• cam tracks

It guides the movement of the punches by controlling the sequence of filling, compression and ejection

• Upper and lower turrets

• Hopper

• Cam tracks

• Feed shoe

It is a separation of tablet into two or more layers.

• Capping

• Sticking

• Picking

• Lamination

It refers when a portion of the material in a tablet is removed

• Double impression

• Sticking

• Picking

• Mottling

It refers to the uneven distribution of color on the tablet.

• Lamination

• Mottling

• Picking

• Capping

This problem is involves only to those punches which have a monogram or other engraving on them.

• Capping

• Double impression

• Mottling

• Picking

It defines the size and shape of the tablets.

• Punches

• Dies

• Hopper

• Feed shoe