Qilu Palonosetron Hydrochloride Injection

What is the strength of Qilu Palonosetron per 5 ml?

• 2.5 mg

• 25 mg

• 25 mcg

• 250 mcg

Qilu Palonosetron belongs to which pharmacological group of antiemetic?

• 5-HT3 antagonist

• Neurokinin-1 antagonist

• Dopamine antagonist

• Benzodiazepine

Which of the following is NOT the indication of Qilu Palonosetron?

• Chemotherapy-induced nausea and vomiting (CINV)

• Prevention of CINV associated with HEC

• Prevention of CINV associated with MEC

• Prevention of CINV associated with LEC

Which of the following cytotoxic agent is NOT a moderately emetogenic chemotherapy?

• Oxaliplatin

• Carboplatin

• Cisplatin

• Irinotecan

Which of the following are the complications of CINV?

• Dehydration & electrolyte imbalance

• Poor quality of life & unable to perform normal daily activities

• Refusal to continue chemotherapy

• Physical & mental deterioration

Which of the following was withdrawn by the FDA because of the possibility of life-threatening cardiac arrhythmias due to QT-interval prolongation?

• Domperidone

• Granisetron

• Dolasetron

• Ondansetron

Choose the most accurate timeline of 5-HT3 antagonist injection being approved by FDA from the earliest to latest.

• Palonosetron, Granisetron, Ondansetron, Dolasetron

• Ondansetron, Granisetron, Dolasetron, Palonosetron

• Dolasetron, Granisetron, Ondansetron, Palonosetron

• Granisetron, Dolasetron, Ondansetron, Palonosetron

Which of the following regarding to palonosetron is/are correct?

• It has the longest half-life among 5-HT3 antagonists

• It is usually use alone as antiemetic for HEC

• It is a 2^nd generation 5-HT3 antagonists

• It can be given intravenously and intramuscularly

Which of the following is NOT the benefit of palonosetron?

• Longer half-life and stronger binding affinity than the first generation 5-HT3 antagonists

• High risk of cardiac QT-interval prolongation

• Single dose regime which improves patient compliance

• None of the above

Which of the following regarding to the manufacturer is FALSE?

• The company was established in 2015

• The manufacturing site is in Haikou city, Hainan, China

• The company name is Qilu Pharmaceutical (Hainan) Co., Ltd

• Palonosetron is their first product registered in Medispec