Comp 1 Kinetics and Dynamics

Which route has the slowest onset of action?

• Intravenous (IV)

• Intramuscular (IM)

• Subcutaneous (SQ)

• Oral (PO)

• Inhaled (INH)

Which phase of pharmacokinetics will be affected in a patient with an elevated Blood Urea Nitrogen (BUN) and Creatine labs?

• Absorption

• Distribution

• Metabolism

• Elimination

Which phase of pharmacokinetics is affected when a patient takes medications with an antacid?

• Absorption

• Distribution

• Metabolism

• Excretion

Which phase of pharmacokinetics would be affected by Grapefruit Juice?

• Absorption

• Distribution

• Metabolism

• Elimination

Which organ(s) is/are responsible for the elimination phase of pharmacokinetics ?

• Stomach & small intestines

• Blood and Plasma Proteins

• Liver

• Kidneys

A medication is more likely to cross the Blood Brain Barrier if it is:

• Water Soluble

• Paradoxical

• Fat Soluble

• Nephrotoxic

Which term refers to potential to cause harm to a fetus

• Synergistic

• Ototoxic

• Teratogenic

• Hepatotoxic

• Paradoxical

When is the best time to draw a PEAK level for an IV medication.

• Halfway between doses

• Just before the next dose

• 30-60 minutes after administration

• 2 hours after administration

Tinnitus and Vertigo are symptoms of which toxicity

• Hepatotoxicity

• Nephrotoxicity

• Neurotoxicity

• Ototoxicity

• Cardiotoxicity

What is the term that refers to the time between administration of a medication and the time it reaches Minimum Effective Concentration?

• Onset

• Elimination

• Peak

• Metabolism

• Duration