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BIOC2: Week 9 - Purines

Authored by Ashley McClelland

Science

University

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BIOC2: Week 9 - Purines
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5 questions

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1.

MULTIPLE CHOICE QUESTION

1 min • 1 pt

What is the required form of folate for purine synthesis?

DHF

N-10-formyl THF

N-5-N-10-methylene THF

THF

2.

MULTIPLE CHOICE QUESTION

1 min • 1 pt

Where does the sugar in synthesized nucleic acids come from?

glucose directly from circulation

ribose from PPP

diet

3.

MULTIPLE CHOICE QUESTION

1 min • 1 pt

SCID is caused by a deficiency of which enzyme?

ADA

PRPP

HGPRT

4.

MULTIPLE CHOICE QUESTION

1 min • 1 pt

A 2 year old male patient presents with intellectual disability, hyperuricemia, chorea (involuntary jerking movements), aggression, and compulsive lip and finger biting. Which reaction is compromised?

IMP + aspartate --> adenylosuccinate

Adenine + PRPP --> AMP

xanthine --> uric acid

Guanine + PRPP --> GMP

5.

MULTIPLE CHOICE QUESTION

2 mins • 1 pt

After missing a few feedings, a newborn becomes quite lethargic, and the parents rush the child to the emergency department. Blood analysis indicates elevated levels of lactate and uric acid and significantly decreased levels of glucose. After stabilizing the child with glucose infusions, a glucagon challenge is given to the infant, and blood glucose levels do not increase.


The accumulation of which metabolite in the liver is most responsible for the elevated uric acid seen in the circulation?

glucose

lactate

ribose-5-P

thymidine

acetoacetate

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