Phage Therapy

What are bacteriophages?

• Viruses that target bacterial cells within human cells

• Viruses that target other viruses

• Bacteria that target other viruses within human cells

• Viruses that target bacteria

Which are the 6 nosocomial bacteria that can exhibit multidrug resistant properties?

Hint: ESKAPE!

• E faecium, S. pneumoniae, K. pneumoniae, A. baumannii, Pseudomonas aeruginosa, and Enterobacter spp

• E coli, S. aureus, K pneumoniae, A. baumannii, Ps. aeruginosa, and Enterobacter spp

• Enterobacter spp, S aureus, K. pneumoniae, A baumannii, Ps. aeruginosa, and E. faecium

• Enterobacter spp, S. aureus, K. pneumoniae, A.baumannii, B. pseudomallei, and E. faecium

Which type of bacteriophages (phages) will be preferred in the production of phage therapy against bacterial infections?

• Lytic phages

• Lysogenic phages

• Both lytic or lysogenic phages are suitable

• Prophage

Identify the possible usage of phage therapy against bacterial infections

• Personalised phage therapy against resistant bacterial infections

• Adjunctive therapy with antibiotics

• Localised phage therapy may be created and administered

• All of the above

Which of the options best describe the limitations of phage therapy?

• Bacteria may have phage resistance, which renders phage therapy ineffective

• Use of phage therapy is not ethical as viruses are being used, hence there will be regulatory issues

• Pharmacokinetics of phage therapy is unknown as there are no pharmacokinetics studies

• Good manufacturing practice (GMP) production of phage therapy is unattainable