DR. SMITH ENDO EXAM 3, PPTX 4

What is the mechanism of action of SGLT2?

• Reduce reabsorption of glucose

  and increase urinary glucose

  excretion

• Peroxisome Proliferator

  Activated Receptor Gamma

  agonist increase insulin

  sensitivity (increases uptake /

  utilization of glucose)

• Stimulate insulin

  secretion

• Stimulate insulin

  secretion to

  decrease post

  prandial glucose.

Which box warning is associated with SGLT2?

• Increased risk of leg/foot amputation

• May cause or exacerbate HF

• Lactic acidosis

• Acute pancreatitis

Which of the following is a contraindication for SGLT2?

• Severe renal impairmen t ( eGFR < 30 mL/min/1.73m2 ,

  ESRD, dialysis)

• Class III/IV HF

• Sulfa allergy

• Do not take with Gemfibrozil

What are the adverse effects of SGLT2?

• Weight loss

• Ketoacidosis

• Hypoglycemia

• genital mycotic infection

• hypotension

Hyperkalemia is a unique side effect with Invokana

• True

• False

What is the % reduction of A1c with SGLT2?

• 0.7-1%

• 1.5-2%

• 0.5-1%

Invokanna and Jardiance are approved to reduce risk of

cardiovascular mortality in patients with T2DM and

ASCVD

• True

• False

Yeast infections and/or UTIs may occur while taking SGLT2

• True

• False

100mg prior to 1 st meal of day (max 300 mg)

• Invokana

• Farxiga

• Jardiance

•

5mg in the morning (10mg max)

• Farxiga

• Jardiance

• Jardiance