Metabolism of special lipids

Which of the following are not true about lipid rafts?

• Has cholesterol and sphingomyelin

• found in the outer leaflet of the plasma membrane

• Functions in membrane signaling and trafficking

• can't have protein

Under glycerophospholipids, which of the polar head groups are not included?

• Serine

• Inositol

• Ether

• Choline

In the synthesis of glycerophospholipids, what does Cytidine triphosphate do?

• Activates a headgroup by phosphorylation

• Releases Cytidine monophosphate

• Dephosphorylates phosphatidic acid to 1,2-diacylglycerol

There are two pathways in glycerophospholipid synthesis. Find the odd one out.

• Phosphatidylserine

• Phosphatidylinositol

• Phosphatidylethanolamine

• Phosphatidylcholine

Which of the following statements are false regarding the synthesis of ether glycerolipids?

• precursor is dihydroxyacetone

• Forms 1-alkyl glycerol-3-phosphate

• Biosynthesis is located in the mitochondria

• Involves the enzyme 1-alkylDHAP reductase

A baby was found to have Rhizomelic shortening of their long bones, joint contractures, nasal hypoplasia and Ichthyosis. The doctor diagnosed him with Rhizomeric chondrodysplasia punctata. What caused this?

• Ethanolamine in plasmalogen synthesis

• Impairment in plasmalogen biosynthesis

• Presence of an enzyme that desaturates the alkyl chain

• The oxidation of NADH to NAD+

Which of the following phospholipases is matched correctly with their function?

• Phospholipase A1 - Acts on Sn3 position

• Phospholipase C - Acts on Sn2 position

• Phospholipase B - Acts on Sn1 position

• Phospholipase D - Acts on Sn2 position

Which of the following main classifications of lipids functions as the antigenic determinants of ABO blood groups?

• Glycerolipids

• Sphingolipids

• Phospholipids

• None of the above

Which of the following glycolipids does not contain galactose?

• Galactocerebroside

• Sulfatide

• Glucocerebroside

• Globoside

What disease results from the accumulation of glucocerebroside and the deficiency in beta-Glucosidase?

• Fabry's Disease

• Nielmann-Pick Disease

• Tay-Sachs Disease

• Gaucher's Disease