Diuretics- Khan

Which of the following is not a thiazide or thiazide -like diuretic?

• Hydrochlorothiazide

• Chlorothiazide

• Chlorthalidone

• Torsemide

Which of the following is essential for thiazide activity?

• Electron withdrawing group at position 6

• Sulfonamide group at position 7

• Alkyl substitution with CH3 on the 2-N position

• Hydrophobic substitution at position 3

• Saturation of 3-4 bond

Which of the following increases the potency for thiazides?

• Electron withdrawing group at position 6

• Sulfonamide group at position 7

• Alkyl substitution with CH3 on the 2-N position

• Hydrophobic substitution at position 3

• Saturation of 3-4 bond

Which of the following increases the duration of action for thiazides?

• Electron withdrawing group at position 6

• Sulfonamide group at position 7

• Alkyl substitution with CH3 on the 2-N position

• Hydrophobic substitution at position 3

• Saturation of 3-4 bond

Thiazides act on which part of the nephron?

• Proximal Tubule

• Distal Tubule

• Loop of Henle

• Medullary collecting duct

Which transporter is inhibited by thiazides?

• apical membrane NaCl co-transporter

• basolateral membrane Na/K ATPase

• basolateral membrane Cl channels

• apical membrane calcium channel

What effects do thiazides have when combined with other classes of antihypertensives?

• additive

• synergistic

• antagonistic

• no effect

Giving patients with nephrogenic diabetes insipidus thiazides ___________ urine volume.

• increases

• decreases

What are the acute antihypertensive effects of thiazides?

• increase sodium excretion

• increase intravascular volume

• increase cardiac output

• decrease blood pressure

Answer explanation

decreases intravascular volume and cardiac output

What is the chronic antihypertensive effects of thiazides?

• Normal volume

• Normal cardiac output

• decreased vascular resistance

• decreased blood pressure