PCC2 Exam 1 - Biopharm

An ideal drug delivery system aids in the optimization of drug therapy by delivering the appropriate amount of the drug to the site where it is needed the most and at the time when it is most effective

• true
• false

What order is a drug delivered to the target

• delivery vehicle, whole body, target cell/tissue, target
• delivery vehicle, target, target cell/tissue, whole body
• whole body, delivery vehicle, target cell/tissue, target
• whole body, delivery vehicle, target, target cell/tissue

The process of movement of unchanged drug from the site of administration to systemic circulation is known as<br />

• absorption
• excretion
• permeability

There is no correlation between the plasma concentration of a drug and the therapeutic response<br />

• true
• false

What type of molecules are transported in the body through simple diffusion

• mostly lipophilic, small molecules
• ions (Na, K, Ca)
• most small molecules, certain ions (Na/K pump)
• mostly proteins, certain small molecules and small particles

What type of molecules are transported in the body through facilitated diffusion

• mostly lipophilic, small molecules
• ions (Na, K, Ca)
• most small molecules, certain ions (Na/K pump)
• mostly proteins, certain small molecules and small particles

What type of molecules are transported in the body through active transport

• mostly lipophilic, small molecules
• ions (Na, K, Ca)
• most small molecules, certain ions (Na/K pump)
• mostly proteins, certain small molecules and small particles

What type of molecules are transported in the body through transcytosis

• mostly lipophilic, small molecules
• ions (Na, K, Ca)
• most small molecules, certain ions (Na/K pump)
• mostly proteins, certain small molecules and small particles

Permeability depends on ___ and ___

• the properties of the solute
• the properties of the membrane
• the properties of the solvents<br />

What is a major determinant of cell membrane permeability

• lipophilicity
• partition coefficient
• hydrophillic