Nonlinear pharmacokinetics

In...................... pharmacokinetic parameters for a drug can change with change in dose.

• Linear pharmacokinetics.

• Non-linear pharmacokinetics.

• Both of them.

• None of them.

Linear pharmacokinetics also referred as.....................

• First order kinetics

• Second order kinetics

• Pseudo order kinetics

• None of the above

In nonlinear pharmacokinetics

• There is lower risk of toxicity

• There is higher of toxicity

• Toxicity potential will not change

Which one of the following statements about Michaelis-Menten kinetics is true.

• Km equals ( substrate ) when V1 = Vmax/2

• Saturation occur when all active site of enzyme are filled

• The value of Vmax depends on concentration of enzyme

• All statements are true

No-linear pharmacokinetics is dose ........................ pharmacokinetics.

• Dependent

• Independent

Non-linearity of kinetics exists when the steady state concentration are directly proportional to the dose.

• True

• False

At low concentration non-linear will follow

• Zero order

• First order

• Second order

One of the causes of nonlinear pharmacokinetics in metabolism process is enzyme induction:

• True

• False

The elimination half-life of a drug that follow saturation kinetics doesn't change as the dose increase.

• True

• False

What (Cp)ss would be achieved by a 500 mg/day dose ?

• 58mg/L

• 43.8mg/L

• 74.2 mg/L

• 88.5mg/L