MI 3.4.3 Quiz Review (Quizizz)

Which of the following is not a purpose of clinical trials?

• to test the safety and efficacy of experimental treatments

• to test the safety and efficacy of new combinations of drugs

• to test the safety and efficacy of new approaches to surgery or radiation therapies

• to test the safety and efficacy of better disease prevention approaches

• to test the safety and efficacy of older diagnostic approaches

Which phase of the clinical trial usually tests larger groups of people like 1000-3000 participants?

• phase II

• phase III

• phase IV

• phase I

• none of the phases tests 1000-3000 participants

Phase IV of a clinical trial

*more than one correct answer

• monitors treatments after phase III

• tests only 100 participants

• looks at side effects before the treatment goes out to market

• usually happens after the treatment went out to market

• is the phase where the trials are reviewed by governing boards before going to market

The best standards for clinical trials should be

• double-blind and controlled.

• double-blind, randomized and controlled.

• single-blind, randomized and controlled.

• orphan trials.

• double-blind only.

This type of trial is used to test two treatments where a participant receives one treatment, then receives the other treatment at the conclusion of the other one.

• single-blind trials

• factorial trials

• orphan trials

• open trials

• crossover trials

The duties of the Institutional Review Board include (*more than one response)

• approving and monitor clinical trials.

• making sure clinical trials are scientifically relevant.

• monitors the side effects of drugs after going to market.

• making sure ethical guidelines are met in a clinical trial.

• approving drugs to go to market.

The term that is used to refer to the concept in clinical trials where the participants and the researchers are unaware of the assignment of treatment groups is called

(a)  

Clinical trials that are set up to test the efficacy of procedures such as surgical techniques and therefore cannot be blind are called

(a)  

This controversy of medical ethics lead to an update of the Nuremberg Codes and the formation of the IRB (Institutional Review Board).

• The Nazi experiments in which a variety of medical experiments were done without the informed consent of its prisoners, often bringing harm and death to the forced participants.

• The Willowbrook Hepatitis Study that was done on institutionalized mentally-challenged children.

• Beecher's review of many clinical trials done at the time which criticized many of the controversial and unethical practices of clinical trials.

• The thalidomide tragedy incident in which the study of a drug led to many birth defects in children born to women to were testing the drug.

• Public Health Service Syphilis Study in which African-American participants with syphilis were not treated to see the natural course of the infection.

Clinical trials are performed to primarily check for (*more than one may be correct)

• optimal dose.

• side effects.

• quickest results.

• initial safety.

• cost.