Group 5 Dr Nell

To what G-proteins does FFAR2 and FFAR3 couple?

• FFAR2= Gi/o-proteins and Gq-proteins  / FFAR3= Gi/o-proteins

• FFAR2= Gi/o-proteins / FFAR3= Gi/o-proteins

• FFAR2= Gq-proteins  / FFAR3= Gi/o-proteins

• FFAR2= Gi/o-proteins and Gq-proteins  / FFAR3= none

What is the function of HDAC’s?

• Induce the transcription of anti-inflammatory genes

• Induce the transcription of pro-inflammatory genes

• Preventing the translation of pro-inflammatory genes

• Preventing the transcription of pro-inflammatory genes

In what cell type does Short Chain Fatty Acids induce apoptosis?

• Microbial products

• Cytokines

• Phagocytes

• Neutrophils

Which SCFA is produced by the gut bacteria in the highest percentage?

• Acetate

• Butyrate

• Propionate

• Lactate

Which SCFA is the main energy source for the cells lining the gut called “colonocytes”?

• Acetate

• Butyrate

• Propionate

• Lactate

Short chain fatty acids are mainly made from

• Probiotic dietary fibers

• Prebiotic dietary fibers

What is the current recommendation for daily fiber intake in females?

• 24 grams

• 29 grams

• 33 grams

• 35 grams

How does LPS translocation induce inflammation?

• Recognition of LBP(LPS-binding protein) by the protein recognition receptor,MyD88

• Through TLR-4 activation

• The production of pro-inflammatory cytokines

• By increasing the permeabilty of the intestinal epithelium

How does adiposity result in reduced oxygenation?

• The regulation of adipocyte metabolism i.e the balance in the uptake of fatty acids by adipocytes and their release into the blood stream.

• The regulation of blood flow into all tissue types.

• The regulation of blood into the adipose tissue.

How lipotoxicity in the liver cause inflammation?

• Increased HDL levels result in TLR-4 mediated transcription of inflammatory mediators.

• Increased HDL levels result in the production of apo-B particles which produce inflammatory markers

• Increased LDL levels result in the production of apo-B particles which produce inflammatory markers

• Increased LDL levels result in TLR-4 mediated transcription of inflammatory mediators.