sas 4 cfu

The patient is started on Gemfibrozil. The major mechanism of action of Gemfibrozil is:

• a. increased excretion of bile acid salts

• b. increased expression of high-affinity LDL receptors

• c. increased lipid hydrolysis by lipoprotein lipase

• d. reduced uptake of dietary cholesterol

Which of the following precautions is advisable when using Lovastatin?

• a. serum transaminase measurements

• b. renal function studies

• c. acoustic measurements

• d. complete blood counts

Which of the following drugs, recommended for lowering of serum cholesterol, inhibits cholesterol synthesis

by inhibiting 3-hydroxy-3-methylglutaryl-coenzyme A reductase?

• a. Clofibrate

• b. Simvastatin

• c. Gemfibrozil

• d. Nicotinic acid

Which of the following best describes a pharmacologic property of amiodarone?

• a. a - adrenergic agonist

• b. B- adrenergic agonist

• c. inhibition of K* channels

• d. activation of Ca2* channels

When used as an antiarrhythmic drug, Lidocaine typically:

• a. increases action potential duration

• b. increases contractility

• c. increases PR interval

• d. reduces abnormal automaticity

If the patient has a history of gout, which of the following drugs is most likely to exacerbate this condition?

• a. Colestipol

• b. Ezetimibe

• c. Gemfibrozil

• d. Niacin

When used as monotherapy, a major toxicity of Gemfibrozil is increased risk of:

• a. bloating and constipation

• b. cholelithiasis

• c. hyperuricemia

• d. liver damage

Class IC antiarrhythmic drugs include:

• a. Disopyramide

• b. Lidocaine

• c. Propafenone

• d. Amiodarone

Cinchonism is observed at toxic drug concentration with what anti-arrhythmic drug?

• a. Quinidine

• b. Ibutilide

• c. Lidocaine

• d. Disopyramide

Lidocaine is what class of antiarrhythmic drug?

• a. class 1C

• b. Class 1A

• C. Class 4

• d. class 1B