MLT 504 -TM IV - Class 2 - Open review

Name 3 types (classes) of Immune Hemolytic Anemias

Answer explanation

Allo

Auto

Drug induced

Which coated cells will be cleared by intravascular hemolysis?

• A positive RBC coated with Anti-D

• O positive patient receiving A positive RBCs

Answer explanation

Intravascular hemolysis is caused by complement coating cells . Anti-D doews not usually bind complement but Anti-A and Anti-B do.

Where does extravascular hemolysis take place?

• Bone marrow & kidneys

• Bone marrow & Spleen

• Spleen & Liver

• Liver & kidneys

What could cause the immune system to fail in AIHA?

Answer explanation

Loss of T supressor cells (in number or function) due to microbial agents or certain drugs

Which antigens would most autoantibodies react with?

• Low incidence antigens

• High incidence antigens

Which of the following tests best helps to determine if an autoantibody is present?

• Antibody screen

• ABO typing

• Auto control

• Compatibility testing

Is it possible to have a positive DAT with no detection of hemolytic anemia?

• YES

• NO

Which immunoglobulin type is usually associated with intravascular hemolysis?

• IgG

• IgA

• IgM

• IgE

What type of reagent should be used in primary DAT testing?

• Anti-IgG

• Monospecific AHG

• Anti-C3d

• Polyspecific AHG

What characteristic cells will be present in prepared blood smeanrs of uncompensated anemia?

Answer explanation

Increased retics & spherocytes