PK final exam Part II MC and Calculation

During a constant-rate intravenous infusion, steady- state is initially obtained in

approximately __________ half- lives.

• 3

• 5

• 7

• 0

In the IV infusion pharmacokinetic model, if none of the drug undergoes metabolism, Au

infinity should be equal to the

• Infusion rate constant

• Product of kel and the amount of drug in the body

• Product of ko and the amount of drug in the body

• Product of ko and the duration of infusion

In the IV infusion pharmacokinetic model, the rate of drug input is

• First order

• Equal to the rate of drug elimination

• Constant

• Indicated as ka

In the IV infusion pharmacokinetic model, increasing the infusion rate will cause

• A longer time to reach steady state

• A shorter time to reach steady state

• A higher steady state concentration

• A lower steady state concentration

WOTF is the primary purpose of an IV loading dose in clinical practice

• to minimize drug toxicity

• To increase time required to reach steady state plasma concentration

• To tapidly reach therapeutic plasma concentration

• to maximize drug absorption

During a multiple IV bolus dosing regimen, minimum plasma drug concentrations are reached

• At the end of each dosing interval

• Immediately after a dose is given

• .After 5 half lives

• When the maintenance dose is greater than the loading dose

During a multiple IV bolus, which of the following will cause the average steady state drug

concentration to decrease?

• Decrease the dose

• Decrease in the volume of distribution

• Decrease in total body clearance

• Decrease in the elimination rate constant

• Decrease the dosing interval

WOTF statements is correct concerning the average steady state concentration (Css) obtained during repetitive IV bolus dosing

• Decreasing the dosing interval will cause Css to increase

• Css is inversely proportional to the dose

• Total body clearance dose not affect Css

• If the dose and dosing interval increases, Css must also increase

In the IV infusion model, the rate constant ko indicates that

• Drug absorption is first order

• Drug input is by IV bolus

• The rate of drug input is constant

• Drug elimination is zero order

In the IV infusion model, which of the following are units most likely pertains to ko?

• Ml.hr-1

• mg.hr

• mg/hr

• mg/L