Mutations

Which of the following is a classic example of point mutation?

• Phenylketonuria

• Haemophilia

• Thalassemia

• Sickle cell anaemia

All of the statements are correct wrt mutations except

• mutation is continuos

• Mutation is sudden change

• mutation leads to variation

• mutation can change the structure of DNA

What is the substitution of a purine base with a pyrimidine base known as?

• Transversion

• Transition

• Addition

• Deletion

What is translocation?

• Shifting of part of chromosomes to the outside wall of nucleus

• Shifting of a chromosome to another chromosome

• Shifting of a part of a chromosome to another homologous chromosome

• Shifting of a part of a chromosome to another non-homologous chromosome

Ames test are used ........

• To check whether a perticular compound is toxic or not

• to check carcinogenic ability of compound

• to check medicinal property of a compound

• To check ability of compound to cure disease

Which of the following is non ionizing radiation responsible for mutation?

• X rays

• beta rays

• uv rays

• all of the above

When the mutation occurs on the basis of direction and when it occurs from normal type of allele to mutant allele are known as ………………

• Forward mutation

• Spontaneous mutation

• Reverse mutation

• Germinal mutation

In order to cause a frame shift mutation, ______ must occur.

• A substitution mutation leading the insertion of a U for a G

• A nonsense mutation leading to protein termination

• A missense mutation causing the insertion of a hydrophobic amino acid

• One or two nucleotides must be inserted or deleted in the coding region

Nonsense mutations occur when---------

• Genes in chromosome mutate and code for incorrect DNA

• The new codon codes for stop codon

• Chromosomes break, causing a loss of DNA

• The loss or gain of 1 or 2 nucleotides that affects the coding for a protein.

Mut H,L,S proteins are involved in

• recombination repair

• direct repair

• mismatch repair

• Non homologous end joining