SULFONAMIDES & COTRIMOXAZOLE - AI-M

What is the mechanism of action of sulfonamides?

• Inhibition of folic acid synthesis

• Inhibition of bacterial DNA synthesis

• Inhibition of bacterial protein synthesis

• Inhibition of bacterial ribosome synthesis

What is the primary use of sulfonamides?

• Treatment of respiratory infections
• Treatment of urinary tract infections
• Treatment of skin infections
• Treatment of sexually transmitted infections

What is the most common adverse effect of sulfonamides?

• Hypersensitivity reactions

• Nausea

• Dizziness

• Headache

Which of the following is a common interaction of sulfonamides?

• Increased risk of bleeding with warfarin
• Decreased effectiveness of birth control pills
• Decreased effectiveness of methotrexate
• Increased risk of kidney damage with NSAIDs

What is the mechanism of action of cotrimoxazole?

• Inhibition of bacterial cell wall synthesis

• Inhibition of bacterial DNA synthesis

• Inhibition of bacterial protein synthesis

• Inhibition of folic acid synthesis

Which of the following is an indication for the use of cotrimoxazole?

• Pneumonia
• Otitis media
• Sinusitis
• All of the above

How is cotrimoxazole metabolized in the body?

• By the liver
• By the kidneys
• By the gut microbiota
• By the respiratory system

What is the most common adverse effect of cotrimoxazole?

• Hypersensitivity reactions

• Nausea

• Dizziness

• Headache

Which of the following is a contraindication for the use of cotrimoxazole?

• History of allergic reaction to sulfonamides
• Severe liver disease
• Pregnancy
• All of the above

COTRIMOXAZOLE is combination of

• SULFAMETHOXAZOLE + TRIMETHOPRIM

• SULFODOXINE + PYRIMETHAMINE

• IT IS NOT A COMBINATION

• SULFAMETHOXAZOLE + PYRIMETHAMINE