Introduction to Epigenetic Epidemiology

'The epigenome of a cell can be influenced by the underlying genetic architecture (the DNA) of that cell'. Is this statement true or false?

• TRUE

• FALSE

'The epigenome of a cell cannot be influenced by environmental exposures'. Is this statement true or false?

• FALSE

• TRUE

'The epigenome of a cell can change randomly over time'. Is this statement true or false?

• FALSE

• TRUE

Which of the following can be considered epigenetic mechanisms?

(select ALL that apply)

• Histone Variants

• Protein Phosphorylation

• All Gene Regulatory Mechanisms

• DNA Methylation

• de novo genetic mutations

'In DNA methylation, a _____ group attaches to a _____ base and turns it into _____'. Select the correct words to fill in the blanks

• methyl, cytosine OR guanine, inactive DNA

• methyl, cytosine, 5-methylcytosine

• methyl, guanine, 5-methylguanine

• methyl, guanine, 5-methylguanine

• phosphoryl, cytosine, active DNA

When DNA methylation occurs in the promoter region of a gene, does this canonically switch the gene on or off?

• Off

• On