Blood

24 year old African American man is rushed to the ER 3 hours after the onset severe back and chest pain which started when he was climbing up a mountain. He had an episode of the same symptoms five years ago.

His values are:

Hb:11g/dl

TLC:12000/mm

What is the diagnosis of the patient

• Sickle cell anemia

• Favism

• Renal disease

• Acute blood loss

• Chronic blood loss

Cause of pernicious anemia

• Lack of folic acid

• Lock of vitamin B12

• Hemolysis of RBCs

• Lack of intrinsic factor

From which donor/donors can an A+ patient recieve blood from?

• O-

• B-

• AB+

• A+

Indications of blood transfusion (4 indicators):

Answer explanation

4 indicators:

Circulatory shoc

Severe anemia

Sever leukopenia

Haemorrhagic diseases

An athlete, who comes from a country with high mountains, always wins international races. His investigations, each time after the race, always show higher O2 saturation

What could be the possible explanation?

• Presence of fetal Hb

• Presence of MetHb

• Presence of 2,3 BPG

• Presence of adult hemoglobin 2

Which coenzyme is required for porphyrin synthesis

• Thiamine

• Cyano Cobalamin

• PLP

• vitamin B6

• Pyridoxal phosphate

What is number 4, and what od they contain?

• Beta granule

  Histamine and coagulation factors

• Alpha granule

  Fibrinogen and coagulation factors

• Lambda granule

  Lysosomal enzymes

• Delta granule

  Fibrinogen and histamine

• Alpha granule

  Histamine, seretonin, ATP, ADP

Total number of ATP produced aerobically from glucose in glycolysis step with arsenate

• 0 ATP

• 6 ATP

• 8 ATP

• 2 ATP

• 38 ATP

Answer explanation

Arsenate interferes wth production of 2 ATP at substrate level

Which of the following reactions occurs in fructose metabolism

• Fructose is produced from glucose by aldose reductase

• Sorbitol is produced from glucose by aldose reductase

• Fructose is produced from glucose by sorbitol dehydrogenase

• Sorbtiol is produced from glucose by sorbitol dehydrogenase

Which enzyme os most probably deficient in a pateint with enlarged liver and hypoglycemia in fasting

• glucose-6-phosphokinase

• glucose-6-phosphate dehydrogenase

• glucose-6-phosphatase

• hexokinase

• fructose-6-phosphatase