Myeloproliferative Disorders

The BCR-ABL gene leads to

• increased RBC production

• increased tyrosine kinase activity

• teardrop cells

• decreased platelet count

The origin of leukoerythroblastosis in PMF occurs as a result of:

• Extramedullary hematopoiesis

• presence of teardrop cells in PMF

• infiltration of fibrotic tissue in PMF

• increase in megakaryocytes in PMF

Thrombotic symptoms in PV are generally related to

• hyperviscosity syndrome

• increased M:E ratio

• Increased LAP

• splenomegaly

The diagnostic criteria for essential thrombocythemia includes all of the following criteria except:

• increased platelet count

• absence of philadelphia chromosome

• increased hematocrit

• absence of significant fibrosis and teardrop cells

A dry tap is a characteristic of:

• ET

• PV

• CML

• PMF

What effect does the presence of the BCR-ABL gene have on the prognosis of CML?

• It is not predictive of the diagnosis or prognosis

• Prognosis is better with presence of BCR-ABL gene

• Prognosis is worse

• Disease is more likely to transform to AML

Which of the following does not cause secondary polycythemia

• Chronic obstructive pulmonary disease

• smoking

• emphysema

• dehydration

Extensive BM fibrosis, leukoerythroblastic PB, and the presence of dacrocytes are most characterized with:

• CML

• PV

• ET

• PMF

The Philadelphia chromosome results from a translocation of which chromosomes?

• 8 and 14

• 9 and 22

• 9 and 15

• 8 and 22

PV can be distinguished from secondary polycythemia by measuring:

• hematocrit

• plasma volume

• hemoglobin

• erythropoientin levels