Myelodysplastic syndromes

Which of the following is the predominant RBC morphology in patients with MDS?

• Microcytes

• Macrocytes

• Target cells

• Bite cells

Which diagnosis has the best prognosis?

• MDS with Excess blasts (RAEB)

• Refractory anemia with ringed sideroblasts (RARS)

• Refractory anemia (RA)

• 5q deletion

What is considered a significant percentage of ringed sideroblasts in the MDS classification?

• 15%

• 5%

• 10%

• 20%

Which of the following BM blast percentages would be consistent with myelodysplastic syndrome with excess blast 2 (RAEB)?

• 10%-19%

• 20%-30%

• >30%

• <5%

Which of the following morphological abnormalities are helpful in the diagnosis of MDS?

• Pseudo-Pelger Huet

• Ringed sideroblasts

• Pancytopenia

• All noted here

In female patients with RA and elevated platelet counts, which chromosome abnormality is most often found?

• 5q-

• t(8;21)

• 7q-

• t(15;17)

Which of the following anomalies are important in the pathogenesis of MDS?

• Chromosomal translocations

• Chromosomal deletions

• hemolysis

• Increased medullary apoptosis

In addition to the number of blasts, what other criterion is essential for diagnosis of RARS?

• At least 15% ringed sideroblasts

• at least 30% ringed sideroblasts

• dyshematopoiesis in all 3 cell lines

• pancytopenia

The most common cytopenias noted in MDS is

• leukopenia

• thrombocytopenia

• anemia

• a combination of two of these listed

Progression of MDS to acute leukemia is characterized by:

• splenomegaly

• a decreased M:E

• decreased BM cellularity

• an increase in blast population