CHF Part 2 (all but comborbidities) - Andrews

What drugs induce or exacerbate HF by having negative inotropic effects

• Non-DHP CCB (verapamil, diltiazem)
• NSAIDs, COX-2 inhibitors
• androgens, estrogens, glucocorticoids
• thiazolidinediones (rosiglitazone, pioglitazone)

What drugs induce or exacerbate HF through sodium and water retention

• Non-DHP CCB (verapamil, diltiazem)
• NSAIDs, COX-2 inhibitors
• androgens, estrogens, glucocorticoids
• thiazolidinediones (rosiglitazone, pioglitazone)

What drugs induce or exacerbate HF for miscellaneous reasons

• DPP4 inhibitors (alogliptin and saxagliptin)
• cilostazol
• sympathomimetic (cocaine, caffeine)

If a patient with HF must be on an antiarrhythmic agent with negative inotropic effects, which drugs are preferred

• amiodarone
• dofetilide
• NSAIDs
• rosiglitazone
• pioglitazone

Ejection Fraction (EF) less than 40% is a diagnosis of HFrEF

• True
• False

Drug therapy has clear evidence that drugs improve outcomes for patients with HFpEF

• True
• False

Evidence to suggest improvement in prognosis is overwhelming for patients with HFrEF

• True
• False

Drugs used for HFrEF are also used for HFpEF (or HFmrEF) to treat symptoms or modify risk factors such as HTN

• True
• False

What drugs decrease the morbidity and mortality of HF

• beta blockers, ACE/ARB
• Angiotensin Receptor Neprilysin Inhibitor (ARNI)
• hydralazine and nitrates
• mineralcorticoid/Aldosterone Receptor Antagonists
• sodium glucose co-transporter 2

What drugs decrease the symptoms of HF only

• beta blockers, ACE/ARB
• diuretics
• digoxin
• ivabradine
• sodium glucose co-transporter 2