Pharmacology Quizizz

A 79-year old man with end stage Alzheimer's disease and dysphagia is taking multiple medications. Physical examinations reveal xerostomia and a limited gag reflex. Which of the following routes of medication administration would provide the lowest serum drug concentration?

• Intravenous

• Intramuscular

• Enteral

• Transdermal

• Intrathecal

A 48-year old man with end stage liver disease is hospitalized on the intensive care unit. Review of his blood work reveals elevated liver function tests to five times the normal rate. The patient is receiving multiple intravenous medications. Which of the following medications is likely to be therapeutic for this patient?

• Verapamil

• Epinephrine

• Rifampin

• Erythromycin

A hospitalized patient with systemic candidiasis is receiving intravenous, antifungal medications. He also has hepatic and renal insufficiency. Which of the following lowering drug administration schemes would allow for the most steady amount of drug in the body over a two-week hospitalization period where medication administration will be necessary?

• Once weekly IV injection

• Twice daily IV injection

• Once weekly IV injection

• Continuous IV infusion

The therapeutic index of a drug is the ratio of the dose that produces toxicity to the dose that produces an efficacious response. By this definition, which of the following medications has thr largest therapeutic index?

• Lithium

• Diazepam

• Gentamicin

• Digoxin

A 79-year old man is hospitalized after falling from a cliff. His current medical problems include cardiogenic shock, heart failure,renal disease and cirrhosis from chronic alcoholism. Due to weight loss, he is felt to be somewhat hypermetabolic. Which of the following factors will have the most significant effect to decrease drug-half life of medications administered to him?

• Cardiogenic shock

• Heart failure

• Cirrhosis

• Hypermetabolic state

A 44-year old man with sacral spinal cord injury has atonia of the sigmoid colon and rectum. Despite sacral nerve root stimulation, no normal colorectal function is able to be achieved. Which of the following is true concerning the postganglionic receptors at the distal colon and rectum?

• Exogenous ligand formation is taking place

• The receptors are likely in a transient state

• The active and inactive receptor state are in irreversible equillibrium

• The drugs occupying the receptor are producing conformational changes in the receptor

A novel cholinomimetric agent is being designed to improve salivary glandular secretions in patients with xerostomia. this agent will increase the uptake of choline into cells. This will combine with acetyl coenzyme A which is found in which of the following locations?

• Cytosol

• Golgi apparatus

• Smooth endoplasmic reticulum

• Rough endoplasmic reticulum

What is the definition of pharmacokinetics?

• Mathematical description of the plasma concentration-time course

• Fraction of administered drug that reaches systemic circulation

• Time to peak plasma concentration (t_max)

Total body clearance stands for...

• Reabsorption

• Elimination

• Maintenance

A 74-year old man with moderate stage Alzherimer's disease is seeing his primary care physician. He takes various medications and all are prescription items. He has just begun on memantine 6 months ago and his family notes no difference in his symptoms. What is the most likely explanation for these findings?

• Underlying tinnitus

• interaction with antacids

• interaction with vitamins

• Expected side effect profile

• Drug toxicity